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利用生命病毒介导的人神经元转导研究头塔聚集的体外模型
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JoVE Revista Neurociencias
An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons
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利用生命病毒介导的人神经元转导研究头塔聚集的体外模型

5,686 Views

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05:51 min

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May 23, 2019

DOI:

10.3791/59433-v

DOI:
10.3791/59433-v

•

05:51 min
May 23, 2019

•

20 Views
, , ,
1Department of Neurosciences,University of California, San Diego

Summary

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该协议详细介绍了用慢病毒结构编码为突变体人类 tau 转换人类神经元培养的过程。诱导的区域性显示 tau 聚合和相关的病理。

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Aulston, B., Liu, Q., Reilly, P., Yuan, S. H. An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons. J. Vis. Exp. (147), e59433, doi:10.3791/59433 (2019).

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