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JoVE Journal Neuroscience
An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons
 

An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons

Article DOI: 10.3791/59433-v • 05:51 min • May 23rd, 2019
May 23rd, 2019 •
1, 1, 1, 1
1Department of Neurosciences, University of California, San Diego

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Resumen
Automatic Translation

This protocol details a procedure in which human neuronal cultures are transduced with lentiviral constructs coding for mutant human tau. Transduced cultures display tau aggregates and associated pathologies.

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In Vitro Model Tau Aggregation Lentiviral-mediated Transduction Human Neurons Tauopathy Drug Screening Disease Mechanism Studies Cell Culture Paradigm Tau Toxicity Tau Therapeutics Basement Membrane Matrix Coating Culture Plates Fibroblast Growth Factor Sterile PBS DMEM-F12 Media Neural Stem Cell Media
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