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人类血小板的LC-MS分析作为研究线粒体代谢的平台
 
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人类血小板的LC-MS分析作为研究线粒体代谢的平台

Article DOI: 10.3791/53941-v • 06:04 min • April 4th, 2016
April 4th, 2016 •
*1,2, *2,3, 1,2, 2,3, 2,3, 4, 4, 1,2, 5, 1,2
1Center for Cancer Pharmacology, University of Pennsylvania, 2Center for Excellence in Environmental Toxicology, University of Pennsylvania, 3Penn SRP and Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, 4Division of Traumatology, Department of Surgery, Critical Care and Acute Care Surgery, University of Pennsylvania, 5A.J. Drexel Autism Institute, Drexel University
* These authors contributed equally

Kapitel

Summary
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这里，我们表明分离的人血小板可以用作一个可访问的体外模型来研究的代谢适应响应于I抑制剂鱼藤酮的复合物。这种方法通过液相色谱 - 质谱法使用同位素示踪和相对定量，并且可以应用于各种研究设计的。

Tags

环境科学，第110，代谢示踪剂，血小板，质谱，线粒体，鱼藤酮，异生物质
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