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Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
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神经科学
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JoVE 杂志 神经科学
Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

9,621 Views

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08:33 min

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December 04, 2014

DOI:

10.3791/51853-v

DOI:
10.3791/51853-v

•

08:33 min
December 04, 2014

•

9 Views
, , , , , , , , ,
1Department of Psychiatry,Johns Hopkins University, 2Department of Psychiatry and Behavioral Sciences,Howard University, 3Department of Otolaryngology-Head and Neck Surgery,Johns Hopkins University, 4Department of Psychiatry,Sheppard Pratt Hospital, 5Department of Psychiatry,Indiana University

Summary

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In this study, a novel platform to investigate intraneuronal molecular signatures of treatment response in bipolar disorder (BD) was developed and validated. Olfactory epithelium from BD patients was obtained through nasal biopsies. Then laser-capture microdissection was combined with Real Time RT PCR to investigate the molecular signature of lithium response in BD.

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Olfactory NeuronsNasal BiopsyLaser-capture MicrodissectionBipolar DisorderLithium CarbonateWnt SignalingNeuropsychiatric DisordersOlfactory EpitheliumTreatment Response

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Cite this Article

Narayan, S., McLean, C., Sawa, A., Lin, S. Y., Rai, N., Hipolito, M. S., Cascella, N., Nurnberger, Jr., J. J., Ishizuka, K., Nwulia, E. A. Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders. J. Vis. Exp. (94), e51853, doi:10.3791/51853 (2014).

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