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Neuroscience

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JoVE Journal Neuroscience
Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection
 

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Article DOI: 10.3791/51853-v • 08:33 min • December 4th, 2014
December 4th, 2014 •
1, 2, 1, 3, 2, 2, 4, 5, 1, 2
1Department of Psychiatry, Johns Hopkins University, 2Department of Psychiatry and Behavioral Sciences, Howard University, 3Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, 4Department of Psychiatry, Sheppard Pratt Hospital, 5Department of Psychiatry, Indiana University

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In this study, a novel platform to investigate intraneuronal molecular signatures of treatment response in bipolar disorder (BD) was developed and validated. Olfactory epithelium from BD patients was obtained through nasal biopsies. Then laser-capture microdissection was combined with Real Time RT PCR to investigate the molecular signature of lithium response in BD.

Tags

Olfactory Neurons Nasal Biopsy Laser-capture Microdissection Treatment Response Mental Disorders Bipolar Disorder Pathophysiology Mood Stabilizer Lithium Carbonate Wnt Signaling Olfactory Epithelium Glial-like Supporting Cells Neuropsychiatric Diseases Central Nervous System Dynamic Molecular Changes
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