需要订阅 JoVE 才能查看此. 登录或开始免费试用。
Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation
11,463 Views
•
09:04 min
•
September 07, 2010
DOI:
Summary
Automatically generated
The sialidase assay is a simple technical approach that will elucidate novel molecular mechanism(s) of TLR sensors of microbial infections and involvement in inflammatory diseases at the receptor level on the cell surface of live macrophages.
Explore More Videos
Neu1 Sialidase ActivityTOLL-like Receptor ActivationMammalian Toll-like ReceptorsPathogen-associated Molecular PatternsInfectious DiseasesInflammatory DiseasesAutoimmune DiseasesStructural Integrity Of Sensor ReceptorsLigand InteractionsSignaling ComponentsImmunological ProtectionDisease ModificationLigand-induced TLR ActivationNeu1 Sialidase ActivationNeurotrophin ReceptorsTrkATrkBMatrix Metalloproteinase-9 (MMP-9)Sialidase Assay
Read Article
Cite this Article
Amith, S. R., Jayanth, P., Finlay, T., Franchuk, S., Gilmour, A., Abdulkhalek, S., Szewczuk, M. R. Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation. J. Vis. Exp. (43), e2142, doi:10.3791/2142 (2010).
Copy