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Developmental Biology

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Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids

JoVE Journal
Developmental Biology

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JoVE Journal Developmental Biology

Formation of Human Thymus Organoids in Three-Dimensional Fibrin Hydrogels

Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids

422 Views

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01:31 min

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October 04, 2024

DOI:

10.3791/66795-v

DOI:

10.3791/66795-v

•

01:31 min

October 04, 2024

•

90 Views

Manon d’Arco*¹, Nathan Provin*¹, Pierre Maminirina², Olivier Baron², Carole Guillonneau¹, Laurent David^1,3, Matthieu Giraud¹

¹Nantes Université, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ²CHU Nantes, Nantes Université, Department of Pediatric and Congenital Cardiac Surgery, ³Nantes Université, CHU Nantes, INSERM, CNRS, BioCore, SFR Bonamy

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Thymus Organoids Self-tolerance Autoimmunity Thymic Epithelial Cells Thymopoiesis Cell Therapy Autoimmune Diseases Extracellular Matrix Induced Pluripotent Stem Cells Three-dimensional Hydrogels Thymocyte Progenitors Microenvironment Modeling Cellular Composition Organ Transplantation Functional T Cell Repertoire

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