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Journal
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Biochemistry
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Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays
/
用于评估蛋白水解靶向嵌合体（PROTACS）诱导的三元复合物形成的生物物理测定方法的发展和应用
JoVE Journal
Biochemistry
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JoVE Journal
Biochemistry
The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS)
Please note that all translations are automatically generated.
Click here for the English version.
用于评估蛋白水解靶向嵌合体（PROTACS）诱导的三元复合物形成的生物物理测定方法的发展和应用
Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays
DOI:
10.3791/65718-v
•
01:09 min
•
January 12, 2024
•
Wei Jiang
,
Holly Soutter
1
Center for the Development of Therapeutics
,
The Broad Institute of MIT and Harvard
Tags
Keywords: Biophysical Assays
Ternary Complex Formation
Proteolysis Targeting Chimeras (PROTACs)
Surface Plasmon Resonance (SPR)
Biolayer Interferometry (BLI)
Isothermal Titration Calorimetry (ITC)
Brd4BD2
VHL
PPM1D
Cereblon (CRBN)
Kinetics
Thermodynamics
Cooperativity
Hook Effect
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