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Journal
/
Biochemistry
/
Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays
/
Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation
JoVE Journal
Biochemistry
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JoVE Journal
Biochemistry
Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation
Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation
Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays
DOI:
10.3791/200654-v
•
01:16 min
•
January 12, 2024
•
Wei Jiang
,
Holly Soutter
1
Center for the Development of Therapeutics
,
The Broad Institute of MIT and Harvard
Tags
Isothermal Titration Calorimetry
PROTACS
Ternary Complex Formation
Protein
DMSO
Micro Calorimeter
Titration
Binary Complex
VHL MZ1
Brd4
Positive Cooperativity
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