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Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays
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Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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Biochemie
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JoVE Journal Biochemie
The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS)

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays

DOI:
10.3791/65718-v

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01:09 min

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January 12, 2024

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,
1Center for the Development of Therapeutics,The Broad Institute of MIT and Harvard

Tags

Biophysical AssaysTernary Complex FormationProteolysis Targeting Chimeras (PROTACs)Surface Plasmon Resonance (SPR)Biolayer Interferometry (BLI)Isothermal Titration Calorimetry (ITC)Brd4BD2VHLPPM1DCereblon (CRBN)KineticsThermodynamicsCooperativityHook Effect

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Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation

Biolayer Interferometry (BLI) for Evaluating PROTACS-Induced Ternary Complex Formation

Surface Plasmon Resonance (SPR) for Evaluating PROTACS-Induced Ternary Complex Formation

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