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Transpupillengesteuerte transsklerale Transplantation von subretinalen Transplantaten in einem retinalen Degenerations-Mausmodell
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Transpupillary-Guided Trans-Scleral Transplantation of Subretinal Grafts in a Retinal Degeneration Mouse Model
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Transpupillengesteuerte transsklerale Transplantation von subretinalen Transplantaten in einem retinalen Degenerations-Mausmodell

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806 Views

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07:37 min

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January 26, 2024

DOI:

10.3791/65448-v

DOI:
10.3791/65448-v

•

07:37 min
January 26, 2024

•

3 Views
, , , , , , ,
1Wilmer Eye Institute,Johns Hopkins University School of Medicine, 2Department of Genetic Medicine,Johns Hopkins University School of Medicine

Summary

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Dieses Protokoll stellt einen transpupillengesteuerten transskleralen Ansatz zur sicheren und präzisen Verabreichung subretinaler zellulärer Transplantate mit einer geringen Rate an chirurgischen Komplikationen bei Mäuseempfängern mit oder ohne Netzhautdegeneration dar.

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Cite this Article

Liu, Y. V., Li, K. V., Li, Z., Lu, Y., McNally, M. M., Esposito, E. P., Aziz, K., Singh, M. S. Transpupillary-Guided Trans-Scleral Transplantation of Subretinal Grafts in a Retinal Degeneration Mouse Model. J. Vis. Exp. (203), e65448, doi:10.3791/65448 (2024).

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