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Um modelo esferoide tridimensional para investigar a interação tumoral-estroma em carcinoma hepatocelular
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September 30, 2021
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1Department of Biochemistry, Faculty of Pharmacy,Minia University, 2National Institute for Health Research Birmingham Liver Biomedical Research Unit and Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy,University of Birmingham, 3Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences,Newcastle University, 4Newcastle University Translational and Clinical Research Institute, Faculty of Medical Sciences,Newcastle University, 5The Liver Unit, Department of Medicine, Freeman Hospital,Newcastle-upon-Tyne Hospitals NHS Foundation Trust
Summary
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Modelos in vitro abrangentes que recapitulem fielmente a doença humana relevante estão em falta. O presente estudo apresenta a criação e cultura de spheróides tumorais tridimensionais (3D), uma ferramenta in vitro confiável para estudar a interação tumor-estrommal no carcinoma hepatocelular humano.
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Zaki, M. Y. W., Shetty, S., Wilkinson, A. L., Patten, D. A., Oakley, F., Reeves, H. A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma. J. Vis. Exp. (175), e62868, doi:10.3791/62868 (2021).
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