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September 30, 2021
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1Department of Biochemistry, Faculty of Pharmacy,Minia University, 2National Institute for Health Research Birmingham Liver Biomedical Research Unit and Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy,University of Birmingham, 3Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences,Newcastle University, 4Newcastle University Translational and Clinical Research Institute, Faculty of Medical Sciences,Newcastle University, 5The Liver Unit, Department of Medicine, Freeman Hospital,Newcastle-upon-Tyne Hospitals NHS Foundation Trust
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関連するヒト疾患を忠実に再現する包括的な インビトロ モデルが欠けている。現在の研究は、ヒト肝細胞癌における腫瘍間質相互作用を研究するための信頼性の高い インビトロ ツールである3次元(3D)腫瘍スフェロイドの作成および培養を提示する。
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Zaki, M. Y. W., Shetty, S., Wilkinson, A. L., Patten, D. A., Oakley, F., Reeves, H. A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma. J. Vis. Exp. (175), e62868, doi:10.3791/62868 (2021).
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