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June 05, 2021
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Automatically generated
在这里，我们描述了如何使用自动化大分子晶体学管道进行蛋白质到结构，快速配体 - 蛋白质复合物分析和基于EMBL格勒诺布尔HTX实验室的CrystalDirect技术的大规模片段筛选。
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Automated CrystallographyEMBL HTX FacilityGrenobleCrystalDirect TechnologyCRIM SoftwareCrystal Graphic Information Management SystemCrystallization ProtocolCrystallization ScreensHigh Throughput Crystallization LabAutomated ImagersCRIMSCrystallization PlatesCrystallization ExperimentsCrystal HarvestingProtein Structure DeterminationFragment ScreeningLigand Screening
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Cornaciu, I., Bourgeas, R., Hoffmann, G., Dupeux, F., Humm, A., Mariaule, V., Pica, A., Clavel, D., Seroul, G., Murphy, P., Márquez, J. A. The Automated Crystallography Pipelines at the EMBL HTX Facility in Grenoble. J. Vis. Exp. (172), e62491, doi:10.3791/62491 (2021).
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