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マウスにおける胎児の気管咬合モデル

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Developmental Biology

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JoVE Journal Developmental Biology

Transuterine Fetal Tracheal Occlusion Model in Mice

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マウスにおける胎児の気管咬合モデル

2,855 Views

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06:31 min

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February 05, 2021

DOI:

10.3791/61772-v

DOI:

10.3791/61772-v

•

06:31 min

February 05, 2021

•

3 Views

Emrah Aydın^1,2, Rashika Joshi³, Marc Oria¹, Foong-Yen Lim¹, Brian Michael Varisco³, Jose Luis Peiro¹

¹The Center for Fetal, Cellular & Molecular Therapy, Cincinnati Fetal Center, Division of Pediatric General and Thoracic Surgery,Cincinnati Children’s Hospital Medical Center, ²Department of Pediatric Surgery,Tekirdag Namik Kemal University School of Medicine, ³The Division of Critical Care Medicine, Department of Pediatrics,Cincinnati Children’s Hospital Medical Center

Summary

先天性横隔膜ヘルニアおよび胎児気管閉塞の様々な動物モデルは、倫理的問題、コスト、外科的困難、大きさ、生存率、および遺伝的ツールの入手可能性に関する長所と短所を提示する。このモデルは気管閉塞および上昇した発光圧力が肺の発達に及ぼす影響を調べるための新しいツールを提供する。

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