Journal
/
Neuroscience
/
A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
JoVE Journal
Neuroscience
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Neuroscience
A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

English

Automatically Generated

2,309 Views

•

09:42 min

•

June 04, 2021

DOI:

10.3791/61740-v

DOI:
10.3791/61740-v

•

09:42 min
June 04, 2021

•

8 Views
, ,
1Department of Anesthesiology, Taipei Veterans General Hospital,National Yang-Ming University School of Medicine, 2Department of Neuroscience, Center for Brain Immunology and Glia (BIG),University of Virginia School of Medicine

Summary

Automatically generated

Traditional photothrombotic stroke (PTS) models mainly induce dense platelet aggregates of a high resistance to tissue plasminogen activator (tPA)-lytic treatment. Here a modified murine PTS model is introduced by co-injecting thrombin and photosensitive dye for photoactivation. The thrombin-enhanced PTS model produces mixed platelet:fibrin clots and is highly sensitive to tPA-thrombolysis.

Explore More Videos

Photothrombotic Stroke ModelFibrin-enrichedTPA-sensitiveThrombolytic TherapyBlood ClotAcute Stroke PatientPreclinical Stroke ResearchThrombolytic Therapies

Read Article

Cite this Article

Kuo, Y., Sun, Y., Kuan, C. A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model. J. Vis. Exp. (172), e61740, doi:10.3791/61740 (2021).

Download .ris file

Copy

Share Video

.

Copy