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A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
JoVE 杂志
神经科学
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JoVE 杂志 神经科学
A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

2,309 Views

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09:42 min

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June 04, 2021

DOI:

10.3791/61740-v

DOI:
10.3791/61740-v

•

09:42 min
June 04, 2021

•

8 Views
, ,
1Department of Anesthesiology, Taipei Veterans General Hospital,National Yang-Ming University School of Medicine, 2Department of Neuroscience, Center for Brain Immunology and Glia (BIG),University of Virginia School of Medicine

Summary

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Traditional photothrombotic stroke (PTS) models mainly induce dense platelet aggregates of a high resistance to tissue plasminogen activator (tPA)-lytic treatment. Here a modified murine PTS model is introduced by co-injecting thrombin and photosensitive dye for photoactivation. The thrombin-enhanced PTS model produces mixed platelet:fibrin clots and is highly sensitive to tPA-thrombolysis.

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Cite this Article

Kuo, Y., Sun, Y., Kuan, C. A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model. J. Vis. Exp. (172), e61740, doi:10.3791/61740 (2021).

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