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1Department of Neurology, Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430000, China, 2Key Laboratory of Neurological Diseases of Chinese Ministry of Education, The School of Basic Medicine, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430000,China, 3Department of Pharmacology, School of Basic Medical Science; State Key Laboratory of Medical Neurobiology,Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China
Chapters
- 00:04Introduction
- 01:06Mouse Screening Preparation
- 01:58Chronic Sleep Fragmentation (CSF) Modeling
- 03:04Morris Water Maze (MWM) Test
- 04:00Results: Representative Effects of CSF Modeling on Young Wild-Type Mouse Cognitive Abilities and Anxiety-Like Behaviors
- 05:34Conclusion
Aquí se presenta un protocolo para el modelo de fragmentación crónica del sueño (LCR) logrado por un rotor orbital controlado eléctricamente, que podría inducir déficit cognitivo confirmado y comportamiento similar a la ansiedad en ratones jóvenes de tipo salvaje. Este modelo se puede aplicar para explorar la patogénesis de la alteración crónica del sueño y trastornos relacionados.
