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A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
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JoVE Journal Behavior
A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

DOI:
10.3791/59546-v

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05:28 min

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May 15, 2019

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, , ,
1Department of Anatomy and Convergence Medical Sciences, Institute of Health Sciences, Bio Anti-aging Medical Research Center,Gyeongsang National University Medical School, 2Department of Biological Sciences,Pusan National University, 3Department of Physiology and Convergence Medical Sciences, Institute of Health Sciences,Gyeongsang National University Medical School

Chapters

  • 00:04Title
  • 00:47Induction of Depression
  • 01:45Sucrose Preference Test
  • 02:43Tail Suspension Test
  • 03:40Results: Chronic Immobilization Stress (CIS) Induces Depressive-like Behaviors Well and Releases the Stress Marker Corticosterone
  • 04:16Conclusion

Summary

Automatic Translation

Automatic Translation

This article provides a simplified and standardized protocol for induction of depressive-like behavior in chronically immobilized mice by using a restrainer. In addition, behavior and physiological techniques to verify induction of depression are explained.

Tags

Keywords: Chronic Immobilization StressDepression-like BehaviorMiceTail Suspension TestSucrose Preference TestBody WeightFood Intake

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