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A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
1Department of Neurology, Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430000, China, 2Key Laboratory of Neurological Diseases of Chinese Ministry of Education, The School of Basic Medicine, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430000,China, 3Department of Pharmacology, School of Basic Medical Science; State Key Laboratory of Medical Neurobiology,Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China
Chapters
- 00:04Introduction
- 01:06Mouse Screening Preparation
- 01:58Chronic Sleep Fragmentation (CSF) Modeling
- 03:04Morris Water Maze (MWM) Test
- 04:00Results: Representative Effects of CSF Modeling on Young Wild-Type Mouse Cognitive Abilities and Anxiety-Like Behaviors
- 05:34Conclusion
Presented here is a protocol for chronic sleep fragmentation (CSF) model achieved by an electrically controlled orbital rotor, which could induce confirmed cognitive deficit and anxiety-like behavior in young wild-type mice. This model can be applied to explore the pathogenesis of chronic sleep disturbance and related disorders.
