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Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
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Neuroscience
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JoVE Journal Neuroscience
Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

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9,785 Views

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10:34 min

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August 30, 2020

DOI:

10.3791/61322-v

DOI:
10.3791/61322-v

•

10:34 min
August 30, 2020

•

4 Views
, , , ,
1University of Rouen Normandy, INSERM U1239, DC2N, Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France, 2Department of Anesthesiology and Critical Care,Rouen University Hospital, Rouen, France

Summary

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We described in this protocol a standardized subarachnoid hemorrhage (SAH) mouse model by a double injection of autologous whole-blood into the cisterna magna. The high degree of standardization of the double-injection procedure represents a middle-to-acute model of SAH with relative safety regarding mortality.

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Cite this Article

Pedard, M., El Amki, M., Lefevre-Scelles, A., Compère, V., Castel, H. Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage. J. Vis. Exp. (162), e61322, doi:10.3791/61322 (2020).

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