Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Martin Pedard; Mohamad El Amki; Antoine Lefevre-Scelles; Vincent Comp&#232;re; H&#233;l&#232;ne Castel

doi:10.3791/61322

Journal

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Neurosciences

/

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

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Neurosciences
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Journal JoVE Neurosciences

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

9,785 Views

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10:34 min

•

August 30, 2020

DOI:

10.3791/61322-v

DOI:

10.3791/61322-v

•

10:34 min

August 30, 2020

•

4 Views

Martin Pedard¹, Mohamad El Amki¹, Antoine Lefevre-Scelles^1,2, Vincent Compère^1,2, Hélène Castel¹

¹University of Rouen Normandy, INSERM U1239, DC2N, Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France, ²Department of Anesthesiology and Critical Care,Rouen University Hospital, Rouen, France

Summary

We described in this protocol a standardized subarachnoid hemorrhage (SAH) mouse model by a double injection of autologous whole-blood into the cisterna magna. The high degree of standardization of the double-injection procedure represents a middle-to-acute model of SAH with relative safety regarding mortality.

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Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

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