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Indução de lesão cerebral axonal difusa em ratos com base na aceleração rotacional
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May 09, 2020
DOI:
1Division of Anesthesia and Critical Care, Soroka University Medical Center and the Faculty of Health Sciences,Ben-Gurion University of the Negev, 2Department of Neurosurgery, Soroka University Medical Center and the Faculty of Health Sciences,Ben-Gurion University of the Negev, 3Department of Anesthesiology,Yale University School of Medicine, 4Recanati School for Community Health Professions, Faculty of Health Sciences,Ben-Gurion University of the Negev, 5Department of microbiology and immunology, Faculty of Health Sciences,Ben-Gurion University of the Negev
Summary
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Este protocolo valida um modelo de roedor confiável, fácil de executar e reprodutível da lesão axonal difusa cerebral (DAI) que induz danos generalizados de matéria branca sem fraturas no crânio ou contusões.
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Frank, D., Melamed, I., Gruenbaum, B. F., Grinshpun, J., Kuts, R., Shvartsur, R., Azab, A. N., Assadi, M. H., Vinokur, M., Boyko, M. Induction of Diffuse Axonal Brain Injury in Rats Based on Rotational Acceleration. J. Vis. Exp. (159), e61198, doi:10.3791/61198 (2020).
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