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Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
JoVE Journal
Behavior
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JoVE Journal Behavior
Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

English

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16,468 Views

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14:40 min

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October 27, 2020

DOI:

10.3791/61023-v

DOI:
10.3791/61023-v

•

14:40 min
October 27, 2020

•

57 Views
, ,
1Biology and Chemistry, Synthetic Biology,University of Bremen, 2Advanced Fluorescence Microscopy, Faculty of Biology and Biotechnology,Ruhr-Universität Bochum

Summary

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With optogenetic manipulation of specific neuronal populations or brain regions, behavior can be modified with high temporal and spatial resolution in freely moving animals. By using different optogenetic tools in combination with chronically implanted optical fibers, a variety of neuronal modulations and behavioral testing can be performed.

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Berg, L., Gerdey, J., Masseck, O. A. Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice. J. Vis. Exp. (164), e61023, doi:10.3791/61023 (2020).

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