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心筋梗塞マウスモデルにおける修飾mRNAの導入

JoVE Journal
Genetics

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JoVE Journal Genetics

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model

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心筋梗塞マウスモデルにおける修飾mRNAの導入

8,716 Views

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06:03 min

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June 11, 2020

DOI:

10.3791/60832-v

DOI:

10.3791/60832-v

•

06:03 min

June 11, 2020

•

26 Views

Keerat Kaur^1,2,3, Nishat Sultana^1,2,3, Yoav Hadas^1,2,3, Ajit Magadum^1,2,3, Mohammad Tofael Kabir Sharkar^1,2,3, Elena Chepurko^1,2,3, Lior Zangi^1,2,3

¹Cardiovascular Research Center,Icahn School of Medicine at Mount Sinai, ²Department of Genetics and Genomic Sciences,Icahn School of Medicine at Mount Sinai, ³Black Family Stem Cell Institute,Icahn School of Medicine at Mount Sinai

Summary

このプロトコルは、マウスの心筋梗塞後にmodRNAを使用して、目的の遺伝子を一時的にアップアレートする簡単で一貫した方法を提示する。

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