/

/

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model

JoVE Journal
Genetics

A subscription to JoVE is required to view this content. Sign in or start your free trial.

JoVE Journal Genetics

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model

8,716 Views

•

06:03 min

•

June 11, 2020

DOI:

10.3791/60832-v

DOI:

10.3791/60832-v

•

06:03 min

June 11, 2020

•

26 Views

Keerat Kaur^1,2,3, Nishat Sultana^1,2,3, Yoav Hadas^1,2,3, Ajit Magadum^1,2,3, Mohammad Tofael Kabir Sharkar^1,2,3, Elena Chepurko^1,2,3, Lior Zangi^1,2,3

¹Cardiovascular Research Center,Icahn School of Medicine at Mount Sinai, ²Department of Genetics and Genomic Sciences,Icahn School of Medicine at Mount Sinai, ³Black Family Stem Cell Institute,Icahn School of Medicine at Mount Sinai

Summary

This protocol presents a simple and coherent way to transiently upregulate a gene of interest using modRNA after myocardial infarction in mice.

Explore More Videos

Modified RNA Gene Transfer Myocardial Infarction Ischemia Reperfusion Transverse Aortic Constriction Intratracheal Intubation LAD Ligation Intramuscular Injection

Read Article