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Sintesi dei Peptoidi a informazione e del loro autoassemblaggio covalente dinamico diretto in sequenza
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
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Sintesi dei Peptoidi a informazione e del loro autoassemblaggio covalente dinamico diretto in sequenza

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6,830 Views

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09:34 min

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February 06, 2020

DOI:

10.3791/60442-v

DOI:
10.3791/60442-v

•

09:34 min
February 06, 2020

•

4 Views
, ,
1Department of Chemical Engineering,University of Michigan, 2Department of Chemical Engineering,Monash University, 3Department of Materials Science and Engineering,Monash University

Summary

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Viene presentato un protocollo per la sintesi di oligomeri peptoidi codificati in informazioni e per l'autoassemblaggio di questi peptoidi diretti in sequenza in scale molecolari utilizzando ammine e aldeidi come coppie dinamiche di reazione covalenti e Lewis acida rara terra triflates in metallo come reagenti multiruolo.

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Leguizamon, S. C., Alqubati, A. F., Scott, T. F. Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly. J. Vis. Exp. (156), e60442, doi:10.3791/60442 (2020).

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