Journal
/
Chimie
/
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Journal JoVE
Chimie
This content is Free Access.
Journal JoVE Chimie
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

6,830 Views

•

09:34 min

•

February 06, 2020

DOI:

10.3791/60442-v

DOI:
10.3791/60442-v

•

09:34 min
February 06, 2020

•

4 Views
, ,
1Department of Chemical Engineering,University of Michigan, 2Department of Chemical Engineering,Monash University, 3Department of Materials Science and Engineering,Monash University

Summary

Automatically generated

A protocol is presented for the synthesis of information-encoded peptoid oligomers and for the sequence-directed self-assembly of these peptoids into molecular ladders using amines and aldehydes as dynamic covalent reactant pairs and Lewis acidic rare-earth metal triflates as multi-role reagents.

Explore More Videos

PeptoidsDynamic Covalent Self-assemblySequence-directed AssemblyInformation-directed AssemblyLewis AcidKinetic TrappingCovalent Bond RearrangementFMOC Photolabile Solid Support ResinAutomated Peptide SynthesizerPrimary AmineBromoacetic AcidDICAcetic AnhydrideDMFNMP

Read Article

Cite this Article

Leguizamon, S. C., Alqubati, A. F., Scott, T. F. Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly. J. Vis. Exp. (156), e60442, doi:10.3791/60442 (2020).

Download .ris file

Copy

Share Video

.

Copy