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薬物薬物動態および毒物学的評価のための腸/肝臓微生理学的システム
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Chemistry
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JoVE Journal Chemistry
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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薬物薬物動態および毒物学的評価のための腸/肝臓微生理学的システム

日本語

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7,486 Views

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08:59 min

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December 03, 2020

DOI:

10.3791/60184-v

DOI:
10.3791/60184-v

•

08:59 min
December 03, 2020

•

12 Views
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1Brazilian Biosciences National Laboratory (LNBio),Brazilian Center for Research in Energy and Materials (CNPEM), 2Brazilian Synchrotron Light Laboratory (LNLS),Brazilian Center for Research in Energy and Materials (CNPEM), 3Grupo Boticário, 4Institute of Biology,University of Campinas

Summary

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腸と肝オルガノイドを有する微小生理学的システム(MPS)をアセトアミノフェン(APAP)に曝露した。本稿では、MPSにおけるオルガノイド産生法およびAPAP薬物動態学的および毒性学的特性評価法について説明する。また、結果を検証するために必要な組織機能分析についても説明します。

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Marin, T. M., Indolfo, N. d. C., Rocco, S. A., de Carvalho, M., Dias, M. M., Vasconcelos Bento, G. I., Bortot, L. O., Schuck, D. C., Lorencini, M., Pagani, E. An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment. J. Vis. Exp. (166), e60184, doi:10.3791/60184 (2020).

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