ジャーナル
/
化学
/
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
JoVE Journal
化学
このコンテンツを視聴するには、JoVE 購読が必要です。  サインイン又は無料トライアルを申し込む。
JoVE Journal 化学
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

7,486 Views

•

08:59 min

•

December 03, 2020

DOI:

10.3791/60184-v

DOI:
10.3791/60184-v

•

08:59 min
December 03, 2020

•

12 Views
, , , , , , , , ,
1Brazilian Biosciences National Laboratory (LNBio),Brazilian Center for Research in Energy and Materials (CNPEM), 2Brazilian Synchrotron Light Laboratory (LNLS),Brazilian Center for Research in Energy and Materials (CNPEM), 3Grupo Boticário, 4Institute of Biology,University of Campinas

概要

Automatically generated

We exposed a microphysiological system (MPS) with intestine and liver organoids to acetaminophen (APAP). This article describes the methods for organoid production and APAP pharmacokinetic and toxicological property assessments in the MPS. It also describes the tissue functionality analyses necessary to validate the results.

Explore More Videos

Microphysiological SystemPharmacokinetic AssessmentToxicological AssessmentIntestineLiverDrug TestingIn VitroOrgan-on-a-chipAcetaminophenHPLC AnalysisCell Viability

Read Article

Cite this Article

Marin, T. M., Indolfo, N. d. C., Rocco, S. A., de Carvalho, M., Dias, M. M., Vasconcelos Bento, G. I., Bortot, L. O., Schuck, D. C., Lorencini, M., Pagani, E. An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment. J. Vis. Exp. (166), e60184, doi:10.3791/60184 (2020).

Download .ris file

Copy

Share Video

.

Copy