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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
JoVE Journal
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JoVE Journal Kimya
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

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08:59 min

December 03, 2020

DOI:

08:59 min
December 03, 2020

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We exposed a microphysiological system (MPS) with intestine and liver organoids to acetaminophen (APAP). This article describes the methods for organoid production and APAP pharmacokinetic and toxicological property assessments in the MPS. It also describes the tissue functionality analyses necessary to validate the results.

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