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Ion Mobility-massespektrometri teknikker til bestemmelse af strukturen og mekanismerne for metal Iongenkendelse og Redoxaktivitet af metal bindende oligopeptider
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
DOI:

11:04 min

September 07, 2019

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Chapters

  • 00:04Title
  • 00:58Electrospray-ion Mobility-Mass Spectrometry Analysis
  • 03:02Analysis of ESI-IM-MS pH Titration Data
  • 06:11Collision Cross-Sections and Computational Methods
  • 08:30Results: Reaction Mechanisms and Coordination Sites of the Alternative Methanobactin Complexes
  • 10:00Conclusion

Summary

Automatic Translation

Ion Mobility-massespektrometri og molekylære modelleringsteknikker kan karakterisere den selektive metal chelaterende ydeevne af designede metal bindende peptider og kobber bindende peptid methanobactin. Udvikling af nye klasser af metal Chelat peptider vil hjælpe med at føre til terapeutisk for sygdomme forbundet med metal ionfejl balance.

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