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Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
 

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Article DOI: 10.3791/60102-v • 11:04 min • September 7th, 2019
September 7th, 2019 •
1, 1, 1, 1, 1
1Department of Chemistry, Texas A&M University-Commerce

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Ion mobility-mass spectrometry and molecular modeling techniques can characterize the selective metal chelating performance of designed metal-binding peptides and the copper-binding peptide methanobactin. Developing new classes of metal chelating peptides will help lead to therapeutics for diseases associated with metal ion misbalance.

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Ion Mobility-Mass Spectrometry IM-MS Metal Ion Recognition Redox Activity Metal Binding Oligopeptides Molecular Modeling Metal Correlation Product Ions Mass-to-charge Ratio Arrival Times Stoichiometry Protonation State Conformational Structure Metal Chelating Peptides Therapeutics Menkes Disease Wilson's Disease Cancers Alzheimer's Disease ESI Entrance Tubing Glacial Acetic Acid Ammonium Hydroxide Deionized Water Native ESI-IM-MS Conditions Negative Ion Spectra Positive Ion Spectra Poly-DL-alanine Solution Alternative Methanobactin Solution PH Adjustment
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