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ショウジョウバエを用した疾患関連希少ヒト変異体の生体内機能的研究

JoVE Journal
Genetics

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JoVE Journal Genetics

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

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ショウジョウバエを用した疾患関連希少ヒト変異体の生体内機能的研究

13,327 Views

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00:06 min

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August 20, 2019

DOI:

10.3791/59658-v

DOI:

10.3791/59658-v

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00:06 min

August 20, 2019

•

3 Views

J. Michael Harnish*¹, Samantha L. Deal*², Hsiao-Tuan Chao^1,3,4,5, Michael F. Wangler^1,2,4, Shinya Yamamoto^1,2,4,5

¹Department of Molecular and Human Genetics,Baylor College of Medicine, ²Program in Developmental Biology,Baylor College of Medicine, ³Department of Pediatrics, Section of Neurology and Developmental Neuroscience,Baylor College of Medicine, ⁴Jan and Dan Duncan Neurological Research Institute,Texas Children’s Hospital, ⁵Department of Neuroscience,Baylor College of Medicine

Summary

このプロトコルの目的は、ショウジョウバエメラノガスターにおける生体内実験の設計と性能を概説し、ヒト疾患に関連する希少遺伝子変異体の機能的影響を評価することです。

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