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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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August 20, 2019
DOI:
1Department of Molecular and Human Genetics,Baylor College of Medicine, 2Program in Developmental Biology,Baylor College of Medicine, 3Department of Pediatrics, Section of Neurology and Developmental Neuroscience,Baylor College of Medicine, 4Jan and Dan Duncan Neurological Research Institute,Texas Children’s Hospital, 5Department of Neuroscience,Baylor College of Medicine
Summary
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The goal of this protocol is to outline the design and performance of in vivo experiments in Drosophila melanogaster to assess the functional consequences of rare gene variants associated with human diseases.
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Harnish, J. M., Deal, S. L., Chao, H., Wangler, M. F., Yamamoto, S. In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila. J. Vis. Exp. (150), e59658, doi:10.3791/59658 (2019).
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