Here, we describe a method for reducing the size of zebrafish embryos without disrupting normal developmental processes. This technique enables the study of pattern scaling and developmental robustness against size change.
Ishimatsu, K., Cha, A., Collins, Z. M., Megason, S. G. Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling. J. Vis. Exp. (147), e59434, doi:10.3791/59434 (2019).