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Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
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Genetics
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JoVE Journal Genetics
Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice

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5,944 Views

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08:13 min

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April 10, 2019

DOI:

10.3791/59320-v

DOI:
10.3791/59320-v

•

08:13 min
April 10, 2019

•

3 Views
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1Vascular Biology Center, Medical College of Georgia,Augusta University, 2Renji Hospital, School of Medicine,Shanghai Jiaotong University

Summary

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Here, we present a protocol to transiently improve cardiac function in Duchenne muscular dystrophy mice by transplanting exosomes derived from normal myogenic progenitor cells.

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Duchenne Muscular DystrophyExosomesMyogenic Progenitor CellsCardiac FunctionEchocardiographyUltracentrifugationIntramyocardial Transplantation

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Cite this Article

Su, X., Shen, Y., Jin, Y., Jiang, M., Weintraub, N., Tang, Y. Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice. J. Vis. Exp. (146), e59320, doi:10.3791/59320 (2019).

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