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HIV関連肝病因に対する二重ヒト化TK-NOGマウスモデルの確立
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Immunology and Infection
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JoVE Journal Immunology and Infection
Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
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HIV関連肝病因に対する二重ヒト化TK-NOGマウスモデルの確立

日本語

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8,348 Views

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00:10 min

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September 11, 2019

DOI:

10.3791/58645-v

DOI:
10.3791/58645-v

•

00:10 min
September 11, 2019

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4 Views
, , , ,
1Department of Pharmacology and Experimental Neuroscience,University of Nebraska Medical Center, 2Department of Pathology and Microbiology,University of Nebraska Medical Center

Summary

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このプロトコルは、ヒト免疫系および肝細胞の両方を有するヒト化マウスを確立するための信頼性の高い方法を提供する。ヒト肝細胞およびCD34+造血幹細胞の脾臓内注射を介して達成される二重再構成免疫不全マウスは、ヒト免疫不全ウイルス-1感染の影響を受けやすく、肝臓損傷を再キャパチレートするHIVに感染した患者

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Cite this Article

Dagur, R. S., Wang, W., Makarov, E., Sun, Y., Poluektova, L. Y. Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis. J. Vis. Exp. (151), e58645, doi:10.3791/58645 (2019).

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