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豊かにし、磁性ナノ粒子でまれな抗原特異的 T 細胞を展開

JoVE Journal
Engineering

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JoVE Journal Engineering

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

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豊かにし、磁性ナノ粒子でまれな抗原特異的 T 細胞を展開

11,276 Views

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09:28 min

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November 17, 2018

DOI:

10.3791/58640-v

DOI:

10.3791/58640-v

•

09:28 min

November 17, 2018

•

6 Views

John W. Hickey^1,2,3,4, Jonathan P. Schneck^2,4

¹Department of Biomedical Engineering, School of Medicine,Johns Hopkins University, ²Institute for Cell Engineering, School of Medicine,Johns Hopkins University, ³Institute for Nanobiotechnology,Johns Hopkins University, ⁴Department of Pathology, School of Medicine,Johns Hopkins University

Summary

抗原特異的 T 細胞は特性またはその極低周波による治療を利用しにくい。本明細書で我々はこれらの細胞を豊かにする抗原特異的 T 細胞に結合することができます磁性粒子を開発するためのプロトコルを提供し、それらをいくつか展開する特性評価および治療の両方の 100 倍。

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