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Evaluatie van Zika Virus-specifieke T-cel reacties in Immunoprivileged organen van besmette Ifnar1- / - muizen
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October 17, 2018
DOI:
1School of Laboratory Medicine and Life Sciences,Wenzhou Medical University, 2NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention, 3State Key Laboratory of Agrobiotechnology, College of Biological Sciences,China Agricultural University, 4Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science,Chinese Academy of Sciences, 5Laboratory Animal Center,Chinese Center for Disease Control and Prevention, 6CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology,Chinese Academy of Sciences
Summary
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Een protocol bij het evalueren van antigeen-specifieke T-cel-reacties in de organen van de immunoprivileged van het Ifnar1- / - lymfkliertest model voor de Zika-virus (ZIKV)-infectie wordt beschreven. Deze methode is cruciaal voor het onderzoeken van de cellulaire mechanismen voor de bescherming en immunopathogenese van ZIKV vaccins en is ook waardevol voor de evaluatie van hun doeltreffendheid.
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Cite this Article
Zhang, Y., Zhang, H., Ma, W., Liu, K., Zhao, M., Zhao, Y., Lu, X., Zhang, F., Li, X., Gao, G. F., Liu, W. J. Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice. J. Vis. Exp. (140), e58110, doi:10.3791/58110 (2018).
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