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Rápida detección de los fenotipos del neurodesarrollo en las células precursoras neuronales humanos (PNJ)
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10:47 min
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March 02, 2018
DOI:
1Department of Neuroscience and Cell Biology,Rutgers Robert Wood Johnson Medical School, 2Center for Advanced Biotechnology and Medicine, Department of Neuroscience and Cell Biology,Rutgers Robert Wood Johnson Medical School, 3The Child Health Institute of NJ, Department of Obstetrics, Gynecology, and Reproductive Services,Rutgers Robert Wood Johnson Medical School, 4The Child Health Institute of NJ, Department of Neuroscience and Cell Biology,Rutgers Robert Wood Johnson Medical School, 5Department of Genetics,Rutgers University
Summary
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Desarrollo neurológico procesos como proliferación, migración y consecuencia del neurite son a menudo perturbados en enfermedades neuropsiquiátricas. Así, presentamos protocolos evaluar rápida y reproducible estos procesos del neurodesarrollo en NPCs humanos derivado de iPSC. Estos protocolos permiten la evaluación de los efectos relevantes factores de crecimiento y terapias en desarrollo de NPC.
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Williams, M., Prem, S., Zhou, X., Matteson, P., Yeung, P. L., Lu, C., Pang, Z., Brzustowicz, L., Millonig, J. H., Dicicco-Bloom, E. Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs). J. Vis. Exp. (133), e56628, doi:10.3791/56628 (2018).
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