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Developmental Biology

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JoVE Journal Developmental Biology
Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
 

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Article DOI: 10.3791/56628-v • 10:47 min • March 2nd, 2018
March 2nd, 2018 •
*1, *1, 1, 2, 3, 3, 4, 5, 2, 1
1Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 2Center for Advanced Biotechnology and Medicine, Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 3The Child Health Institute of NJ, Department of Obstetrics, Gynecology, and Reproductive Services, Rutgers Robert Wood Johnson Medical School, 4The Child Health Institute of NJ, Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 5Department of Genetics, Rutgers University
* These authors contributed equally

Capitoli

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Neurodevelopmental processes such as proliferation, migration, and neurite outgrowth are often perturbed in neuropsychiatric diseases. Thus, we present protocols to rapidly and reproducibly assess these neurodevelopmental processes in human iPSC-derived NPCs. These protocols also allow the assessment of the effects of relevant growth factors and therapeutics on NPC development.

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Neurodevelopmental Phenotypes Human Neural Precursor Cells Rapid Detection Extracellular Factors Neuropsychiatry Neurodevelopmental Disorders Cellular Abnormality Neurodegenerative Disorders Neuropsychiatric Disorders Alzheimer's Depression Visual Demonstration Morphological Analyses Cell Detachment Solution Phosphate Buffered Saline
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