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Personlig peptid matriser för detektion av HLA alloantikroppar vid organtransplantation
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1Division of Nephrology and Hypertension, and the Center for Kidney Research and Therapeutics at the Feinberg Cardiovascular Research Institute,Northwestern University Feinberg School of Medicine, 2Surgery-Organ Transplantation,Northwestern University Feinberg School of Medicine, 3School of Biological Sciences and Medical Engineering,Southeast University
Chapters
- 00:05Title
- 00:55Donor and Recipient HLA Sequence Bioinformatic Analysis and Custom Array Synthesis
- 03:19Probe the Pre- and Post-Transplant Sera
- 05:06Data Acquisition and Analysis
- 06:11Results: Representative Recipient anti-Donor HLA Alloantibody Detection
- 07:36Conclusion
Avvikelser i humant leukocyt antigen (HLA) sekvenser mellan organdonator och mottagarens par är den största orsaken för antikroppsmedierad avstötning vid organtransplantation. Här presenterar vi användningen av anpassade antigen matriser som baseras på individuella givarnas HLA sekvenser sond mot givaren HLA alloantikroppar i organ mottagaren.
