/
/
Personalisierte Peptidarrays für die Erkennung von HLA Alloantibodies in Organtransplantation
A subscription to JoVE is required to view this content. Sign in or start your free trial.
1Division of Nephrology and Hypertension, and the Center for Kidney Research and Therapeutics at the Feinberg Cardiovascular Research Institute,Northwestern University Feinberg School of Medicine, 2Surgery-Organ Transplantation,Northwestern University Feinberg School of Medicine, 3School of Biological Sciences and Medical Engineering,Southeast University
Chapters
- 00:05Title
- 00:55Donor and Recipient HLA Sequence Bioinformatic Analysis and Custom Array Synthesis
- 03:19Probe the Pre- and Post-Transplant Sera
- 05:06Data Acquisition and Analysis
- 06:11Results: Representative Recipient anti-Donor HLA Alloantibody Detection
- 07:36Conclusion
Fehlanpassungen in human Leukocyte Antigen (HLA) Sequenzen zwischen Organspender und Empfänger-Paare sind die Hauptursache der Antikörper-vermittelten Ablehnung im Organ-Transplantation. Hier präsentieren wir Ihnen die Verwendung von benutzerdefinierten Antigen-Arrays, die auf einzelnen Spendern HLA Sequenzen, Anti-Spender HLA Alloantibodies in Organempfängern Sonde basieren.
