/
/
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Se requiere una suscripción a JoVE para ver este contenido. Inicie sesión o comience su prueba gratuita.
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
9,953 Views
•
08:07 min
•
September 06, 2017
DOI:
1Division of Nephrology and Hypertension, and the Center for Kidney Research and Therapeutics at the Feinberg Cardiovascular Research Institute,Northwestern University Feinberg School of Medicine, 2Surgery-Organ Transplantation,Northwestern University Feinberg School of Medicine, 3School of Biological Sciences and Medical Engineering,Southeast University
Summary
Automatically generated
Mismatches in human leukocyte antigen (HLA) sequences between organ donor and recipient pairs are the major cause of antibody-mediated rejection in organ transplantation. Here we present the use of custom antigen arrays that are based on individual donors' HLA sequences to probe anti-donor HLA alloantibodies in organ recipients.
Read Article
Cite this Article
Liu, P., Souma, T., Wei, A. Z., Xie, X., Luo, X., Jin, J. Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation. J. Vis. Exp. (127), e56278, doi:10.3791/56278 (2017).
Copy