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A High-throughput Cell Microarray Platform for Correlative Analysis of Cell Differentiation and Traction Forces
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Chapters
- 00:05Title
- 01:05Fabrication of Polyacrylamide Substrates
- 02:57Fabrication of Arrays
- 05:15Cell Culture and Assay Readout
- 09:06Results: Biochemical and Biophysical Cues in Liver Progenitor Differentiation
- 10:58Conclusion
Cell differentiation is regulated by a host of microenvironmental factors, including both matrix composition and substrate material properties. We describe here a technique utilizing cell microarrays in conjunction with traction force microscopy to evaluate both cell differentiation and biomechanical cell–substrate interactions as a function of microenvironmental context.
