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A High-throughput Cell Microarray Platform for Correlative Analysis of Cell Differentiation and Traction Forces
JoVE Journal
生物工学
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JoVE Journal 生物工学
A High-throughput Cell Microarray Platform for Correlative Analysis of Cell Differentiation and Traction Forces

A High-throughput Cell Microarray Platform for Correlative Analysis of Cell Differentiation and Traction Forces

DOI:

12:04 min

March 01, 2017

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  • 00:05標題
  • 01:05Fabrication of Polyacrylamide Substrates
  • 02:57Fabrication of Arrays
  • 05:15Cell Culture and Assay Readout
  • 09:06Results: Biochemical and Biophysical Cues in Liver Progenitor Differentiation
  • 10:58Conclusion

概要

自動翻訳

Cell differentiation is regulated by a host of microenvironmental factors, including both matrix composition and substrate material properties. We describe here a technique utilizing cell microarrays in conjunction with traction force microscopy to evaluate both cell differentiation and biomechanical cell–substrate interactions as a function of microenvironmental context.

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