Two microsurgery approaches for local drug delivery to the inner ear are described here and compared in terms of impact on hearing parameters, cochlear cytoarchitecture and expression of inflammatory markers.
Murillo-Cuesta, S., Vallecillo, N., Cediel, R., Celaya, A. M., Lassaletta, L., Varela-Nieto, I., Contreras, J. A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection. J. Vis. Exp. (121), e54951, doi:10.3791/54951 (2017).