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Biologia
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A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
JoVE Journal
Biologia
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JoVE Journal Biologia
A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

DOI:
10.3791/54951-v

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09:18 min

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March 08, 2017

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, , , , , ,
1Instituto de Investigaciones Biomédicas (IIBm) Alberto Sols CSIC-UAM, 2Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER),Instituto de Salud Carlos III (ISCIII), 3Instituto de Investigación Sanitaria La Paz (IdiPAZ), 4Facultad de Veterinaria,Universidad Complutense de Madrid, 5Departmento de Otorrino laringología,Hospital Universitario La Paz

Capítulos

  • 00:05Título
  • 01:02Auditory Brainstem (ABR) Procedure
  • 03:20Bullostomy
  • 05:57Transtympanic Injection
  • 07:18Results: Maintenance of ABR and Morphology Following Bullostomy and Transtympanic Injection Procedures
  • 08:28Conclusion

Summary

Tadução automática

Tadução automática

Two microsurgery approaches for local drug delivery to the inner ear are described here and compared in terms of impact on hearing parameters, cochlear cytoarchitecture and expression of inflammatory markers.

Tags

Drug DeliveryInner EarMouseBullostomyTranstympanic InjectionHearingCochlear CytoarchitectureAuditory FieldAnimal StudiesMinimally InvasiveHearing LossMicrosurgical ProceduresMiddle EarAnesthetized MouseABRAcoustic StimuliEvoked Response

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