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A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
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生物学
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JoVE Journal 生物学
A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

DOI:
10.3791/54951-v

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09:18 min

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March 08, 2017

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, , , , , ,
1Instituto de Investigaciones Biomédicas (IIBm) Alberto Sols CSIC-UAM, 2Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER),Instituto de Salud Carlos III (ISCIII), 3Instituto de Investigación Sanitaria La Paz (IdiPAZ), 4Facultad de Veterinaria,Universidad Complutense de Madrid, 5Departmento de Otorrino laringología,Hospital Universitario La Paz

章

  • 00:05標題
  • 01:02Auditory Brainstem (ABR) Procedure
  • 03:20Bullostomy
  • 05:57Transtympanic Injection
  • 07:18Results: Maintenance of ABR and Morphology Following Bullostomy and Transtympanic Injection Procedures
  • 08:28Conclusion

概要

自動翻訳

自動翻訳

Two microsurgery approaches for local drug delivery to the inner ear are described here and compared in terms of impact on hearing parameters, cochlear cytoarchitecture and expression of inflammatory markers.

タグ

Drug DeliveryInner EarMouseBullostomyTranstympanic InjectionHearingCochlear CytoarchitectureAuditory Field動物実験Minimally InvasiveHearing LossMicrosurgical ProceduresMiddle EarAnesthetized MouseABRAcoustic StimuliEvoked Response

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